HAN BIOMEDICAL INC.

HAN

BIOMEDICAL

Health Industry

Advanced Technology

Needs of Patients

Innovative Biomaterial

Technology Platform

About HANBIO

HAN BIOMEDICAL INC.

HAN Biomedical is a company devoted in R&D of Healthcare products of Advanced biomaterials to meet patients’ Needs in tissue repair and regeneration.

Corporate Vision and Goal

| Vision |

We develop novel, structured biomaterials for tissue regeneration to fulfill the unmet needs of patients in various tissue repair.

| Goal |

The corporate goal of HAN BIOMEDICAL is to be a global leading company in R&D of biomaterial for tissue repair market.

Corporate Team

The corporate team is including experienced professionals in research & design, commercialization, regulation and marketing of biomaterials.

CorporateCore Value

To comply the market driven R&D strategy

To develop products for relieving the patients’ pain

To cultivate the professionals via team learning process

Technology Platform

Core technology platform
From raw material purification to product design
Scaffold & membrane

Membrane & gel products

Tissue Regeneration & Repair

| Three elements of tissue engineering |

HAN BIOMEDICAL
To be a global leading company in biomaterial for tissue repair market

R&D Strategy

Marketed Product

BarriGel ｜ HANBIO Patient Lubricant

BarriGel Adhesion Prevention Gel

Sterilized, transparent, high viscosity gel

High molecular weight (>1,000,000), not cross-linked sodium hyaluronate

Homogeneous, high viscosity, delayed degradation gel

Good viscoelasticity and easy to apply

Indication: Post-surgical adhesion prevention in gynecological surgeries

Specification: 30mg/ml(5ml & 10ml/ dose) & 40mg/ml(5ml & 10ml/ dose)

Studiesconducted

Including intrinsic viscosity and polymer cross-link density studies

Rat degradation study

CYTOTOXICITY STUDY FOR BIOCOMPATIBILITY
INTRACUTANEOUS REACTIVITY TEST
Hemolytic Properties Study
BACTERIAL REVERSE MUTATION TEST
IN VITRO MAMMALIAN CELL GENE MUTATION TEST
Pyrogen Test
Acute Systemic Toxicity Study in Mice
Implantation Study in Rabbits – Muscle – 4weeks
SKIN SENSITIZATION STUDY GUINEA PIG MAXIMIZATION TEST
14 – Day Subacute Systemic Toxicity Study in Rats

Animal efficacy studies

BarriGel is effec ve in preven on of post-opera ve adhesion

Marketed Product

BarriGel ｜ HANBIO Patient Lubricant

HANBIO Patient Lubricant

Vaginal Gel as vaginal moisturizer for women with genitourinay syndrome

Genitourinay Syndrome of Menopause, GSM

Vaginal dryness
Vaginal burning & irritation
Abnormal discharge

Urinary urgency, frequency
Dysuria
Recurrent UTI

Dyspareunia
Discomfort or pain with sexual activity
Post-coital bleeding

Treatment of genitourinary syndrome

The principal therapeutic goal in the genitourinary syndrome of menopause is to relieve symptoms.
Treatment options include, in addition to local and systemic hormonal therapy,
lifestyle changes and non-hormonal treatments mainly based on the use of moisturizers and lubricants.

VAGINAL LUBRICANTS (Reduce irrita on during intercourse)

MOISTURIZERS (Regular use for relieving GSM symptoms)